The Center for Translational Cancer Research


(In Progress...) Have publications you would like to add to the list? please email them to Benjamin Rohe at



J Blaze, A Asok, and TL Roth. 2015. Long-term effects of early caregiving experiences on bdnf histone acetylation in the adult rat mPFC. Stress, epub ahead of print Aug 25.
S Doherty, A Forster, and TL Roth. 2015. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioral Brain Research, epub ahead of print May 28. (Full Text PDF)
Srinivasan PP, Parajuli A, Price C, Wang L, Duncan RL, Kirn-Safran CB. Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes. PLoS One. 2015 May 26;10(5):e0127290. doi: 10.1371/journal.pone.0127290. (Full Text PDF)
Keller, S.M., Schreiber, W.B., Staib, J.S., Knox, D. (2015). Sex differences in the single prolonged stress model. Behavioural Brain Research 286: 29-32. (Full Text PDF)
Doolan K.M. and Colby D.W., Conformation dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing J Mol. Biol. 427, 328-40, 2015. (Full Text PDF)
Stepicheva, N, Nigam P.A., Siddam A., Peng, CF, J. L. Song.  microRNAs regulate B-catenin of the Wnt signaling pathway in early sea urchin elopementent. Developmental Biology. Jan 19. 2015. Pii: S0012-1606 (15)00016-0. Doi:10.1016/j.ydbio.2015.01.008. PMID:25614238 (Full Text PDF)
Joglekar M, Elbazanti WO, Weitzman MD, Lehman HL, van Golen KL.  Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase. J Cell Biochem. 2015 Jan 5. doi: 10.1002/jcb.25025. [Epub ahead of print]
Szczesny SE, Edelstein RS, Elliott DM (2014) DTAF dye concentrations commonly used to measure microscale deformations in biological tissues alter tissue mechanics. PLoS ONE 9(6): e99588. (Full Text PDF)
Szczesny SE, Elliott DM (2014) Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon. Acta Biomater 10(6): 2582-2590. (Full Text PDF)
Opdenaker LM, Arnold KM, Pohlig RT, Padmanabhan JS, Flynn DC, Sims-Mourtada J.  Immunohistochemical analysis of aldehyde dehydrogenase isoforms and their association with estrogen-receptor status and disease progression in breast cancer.  Breast Cancer (Dove Med Press). 2014 Dec 12;6:205-9. doi: 10.2147/BCTT.S73674. eCollection 2014. (Full Text PDF)
Sims-Mourtada J, Opdenaker LM, Davis J, Arnold KM, Flynn D. Taxane-induced hedgehog signaling is linked to expansion of breast cancer stem-like populations after chemotherapy. Mol Carcinog. 2014 Sep 27. doi: 10.1002/mc.22225. (Full Text PDF)
Jiang, J.L., D.S. Woulfe, and E.T. Papoutsakis, Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells. Blood, 2014. 124(13): p. 2094-2103. (Full Text PDF)
Foster AA, Greco CT, Green MD, Epps TH 3rd, Sullivan MO. Light‐Mediated Activation of siRNA Release in Diblock Copolymer Assemblies for Controlled Gene Silencing." Advanced healthcare materials (2014). (Full Text PDF)
Green MD, Foster AA, Greco CT, Roy R, Lehr RM, Epps TH 3rd, Sullivan MO. "Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery." Polymer chemistry 5, no. 19 (2014): 5535-5541.
Maeda M, Harris AW, Kingham BF, Lumpkin CJ, Opdenaker LM, McCahan SM, Wang W, Butchbach ME. Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells. PLoS One. 2014 Sep 5;9(9):e106818. doi: 10.1371/journal.pone.0106818. eCollection 2014. (Full Text PDF)
Bhatlekar S, Fields JZ, Boman BM. HOX genes and their role in the development of human cancers. J Mol Med (Berl). 2014 Aug;92(8):811-23. doi: 10.1007/s00109-014-1181-y. Epub 2014 Jul 5. (Full Text PDF)
Xu X, Farach-Carson MC, Jia X. Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv. 2014 Nov 15;32(7):1256-68. doi: 10.1016/j.biotechadv.2014.07.009. Epub 2014 Aug 10. (Full Text PDF)
Jansson KH, Castillo DG, Morris JW, Boggs ME, Czymmek KJ, Adams EL, Schramm LP, Sikes RA. Identification of beta-2 as a key cell adhesion molecule in PCa cell neurotropic behavior: a novel ex vivo and biophysical approach.  PLoS One. 2014 Jun 3;9(6):e98408. doi: 10.1371/journal.pone.0098408. eCollection 2014. (Full Text PDF)
Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X.  Hyaluronan: a simple polysaccharide with diverse biological functions.  Acta Biomater. 2014 Apr;10(4):1558-70. (Full Text PDF)
Xu X, Sabanayagam CR, Harrington DA, Farach-Carson MC, Jia X. A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics. Biomaterials. 2014 Mar;35(10):3319-30. doi: 10.1016/j.biomaterials.2013.12.080. Epub 2014 Jan 18. (Full Text PDF)
Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland.  Laryngoscope. 2014 Feb;124(2):456-61. doi: 10.1002/lary.24297. Epub 2013 Aug 6. (Full Text PDF)
Fahmy A. Mamuya, Yan Wang, Victoria H. Roop, David A. Scheiblin, Jocelyn C. Zajac and Melinda K. Duncan. The Roles of αV Integrin in Lens EMT and Posterior Capsular Opacification.  Journal of Cellular and Molecular Medicine, 2014. 18, 656-670. (Full Text PDF)
Abby L. Manthey, Anne M. Terrell, Yan Wang, Jennifer R. Taube, Alisha R. Yallowitz, and Melinda K. Duncan. The Zeb proteins, dEF1 and Sip1, may have distinct functions in lens cells following cataract surgery. Investigative Ophthalmology and Visual Sciences, 2014. 55,
5445-5455. (Full Text PDF)
Song, J.L.  Broad distribution of ARF6 in somatic and germ cells of the sea urchin ovary. Molecular Reproduction and Development. 2014. March 29. doi: 10.1002/mrd.22326
Abby L. Manthey, Salil A. Lachke, Paul G. FitzGerald, Robert W. Mason, David A. Scheiblin, John H. McDonald, and Melinda K. Duncan. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.  Mechanisms of Development, 2014. 131, 86-110 (Full Text PDF)
Stepicheva, Nadezda and J.L. Song.  High throughput microinjections of sea urchin zygotes. Journal of Visualized Experiments. 2014. Jan 21;(83):e50841. doi: 10.3791/50841. (Full Text PDF) (Link to Jove Video)
Pradhan-Bhatt S, Harrington DA, Duncan RL, Jia X, Witt RL, Farach-Carson MC. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A. 2013 Jul;19(13-14):1610-20. doi: 10.1089/ten.TEA.2012.0301. Epub 2013 May 10. (Full Text PDF)
R.J. Schaefer, R. Russell, H. Akkiraju, J. C. Bonor, K. L. van Golen, and A Nohe. Targeting of calcitriol to inflammatory breast cancer tumors and metastasis in vitro and in vivo. Journal of Organ Biology, Biological Systems. 2013.
Sharmila Chatterjee, Yan Wang, Melinda K. Duncan and Ulhas P. Naik.  Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PLoS one 2013. 8(5):e63674. (Full Text PDF)
Martin BJ, van Golen KL.  A comparison of cholesterol uptake and storage in inflammatory and noninflammatory breast cancer cells. Int J Breast Cancer. 2012;2012:412581. doi: 10.1155/2012/412581. Epub 2012 Dec 31. (Full Text PDF)
Bhagwat V. Alapure, Jaime K. Stull, Zeynep Firtina and Melinda K. Duncan. The Unfolded Protein Response is activated in Connexin50 mutant mouse lenses.  Experimental Eye Research. 2012. 102, 28-37. (Full Text PDF)
Song, J.L. and G.M. Wessel. The forkhead transcription factor FoxY regulates nanos. Molecular Reproduction & Development. 2012. 79(10):680-8.(Full Text PDF)
Gurski LA, Xu X, Labrada LN, Nguyen NT, Xiao L, van Golen KL, Jia X, Farach-Carson MC.  Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. PLoS One. 2012;7(11)    (Full Text PDF)
Song, J.L., M. Stoeckius, J. Maaskola, M. Friedlaender, Nadezda Stepicheva, C. Juliano, S. Lebedeva, W. Thompson, N. Rajewsky, and G.M. Wessel. Select microRNAs are essential for early development in the sea urchin. Developmental Biology. 2012. 362(1):104-113.   (Full Text PDF)
Xu X, Gurski LA, Zhang C, Harrington DA, Farach-Carson MC, Jia X.  Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids. Biomaterials. 2012 Dec;33(35):9049-60.  (Full Text PDF)
Chung SW, Cooper CR, Farach-Carson MC, Ogunnaike BA.  A control engineering approach to understanding the TGF-β paradox in cancer.  J R Soc Interface. 2012 Jun 7;9(71):1389-97. doi: 10.1098/rsif.2011.0799. Epub 2011 Dec 21. (Full Text PDF)
Thompson WR, Carter R, Rohe B, Duncan RL, Cooper CR. A novel massage therapy technique for management of chronic cervical pain: a case series. Int J Ther Massage Bodywork. 2011;4(3):1-7. Epub 2011 Sep 30. (Full text PDF)

Kuczmarski JM, Darocki MD, DuPont JJ, Sikes RA, Cooper CR, Farquhar WB, Edwards DG.  Effect of moderate-to-severe chronic kidney disease on flow-mediated dilation and progenitor cells.  Exp Biol Med (Maywood). 2011 Sep;236(9):1085-92. doi: 10.1258/ebm.2011.011008. Epub 2011 Jul 26. (Full text PDF)
Warren CR, Catts ZA, Farach-Carson MC.  A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin. Exp Cell Res. 2011 Sep 10;317(15):2099-109. doi: 10.1016/j.yexcr.2011.06.010. Epub 2011 Jun 29.   (Full text PDF)
Zhang C, Soori M, Miles FL, Sikes RA, Carson DD, Chung LW, Farach-Carson MC.  Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. Prostate. 2011 Feb 1;71(2):157-67. doi: 10.1002/pros.21231. (Full text PDF)
Firtina, Z., Duncan, M.K., 2011. Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr. Patterns 11, 135-143. (Full Text PDF)
Wang X, Gurski LA, Zhong S, Xu X, Pochan DJ, Farach-Carson MC, Jia X.  Amphiphilic Block Co-polyesters Bearing Pendant Cyclic Ketal Groups as Nanocarriers for Controlled Release of Camptothecin. J Biomater Sci Polym Ed. 2010 Jun 30. (Full Text PDF)
Gurski LA, Petrelli NJ, Jia X, and Farach-Carson MC.  Three-dimensional matrices for anti-cancer drug testing and development.  Oncology Issues 2010; 25:20-25 (Full Text PDF)

Li Y, Galileo DS Soluble L1CAM promotes breast cancer cell adhesion and migration in vitro, but not invasion. Cancer Cell Int. 2010 Sep 15;10:34. (Full Text PDF)

Pradhan S, Liu C, Zhang C, Jia X, Farach-Carson MC and Witt RL.  Lumen formation in three-dimensional cultures of salivary acinar cells.  Otolaryngology - Head and Neck Surgery.  2010; 142:191-195 (Full Text PDF)

Pradhan S and Farach-Carson MC.  Mining the extracellular matrix for tissue engineering applications. Regenerative Medicine. 2010; 5(6): 961-970 (Full Text PDF)

Thompson WR, Modla S, Grindel BJ, Czymmek KJ, Wang L, Duncan RL, Farach-Carson MC. Perlecan/Hspg2 Deficiency Alters the Pericellular Space of the Lacuno-Canalicular System Surrounding Osteocytic Processes in Cortical Bone. Journal of Bone and Mineral Research. 2010 Sep 2. [Epub ahead of print] (Full Text PDF)
Wang X, Gurski LA, Zhong S, Xu X, Pochan DJ, Farach-Carson MC, Jia X.  Amphiphilic block copolyesters bearing pendant cyclic ketal groups as nanocarriers for controlled release of camptothecin.  J Biomat Sci-Polym E 2010 in press.
Zhang C, Soori M, Miles FL, Sikes RA, Carson DD, Chung LW and Farach-Carson MC. Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. The Prostate. 2010. E-Publish ahead of print. (Full Text PDF)

Dharmaraj N, Gendler SJ, Carson DD. Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model. Biol Reprod. 2009. 81(6):1182-1188. (Full Text PDF)

Griffiths GS, Galileo DS, Aravindan RG, Martin-DeLeon PA. Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes. Biol Reprod. 2009. 81(3):562-70. (Full Text PDF)

Gurski LA, Jha AK, Zhang C, Jia X, and Farach-Carson MC.  Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells.  Biomaterials 2009; 30:6076-6085 (Full Text PDF)

Naik, MU, Nigam, A, Manrai, P, Millili, P, Czymmek, K, Sullivan, M and Naik, UP. CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3. J Thrombosis Haemostasis. 2009. 7: 1906–1914. (Full Text PDF)

Pradhan S, Zhang C, Jia X, Carson DD, Witt R and Farach-Carson MC.  Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro.  Tissue Engineering: Part A. 2009; 15:3309-3320 (Full Text PDF)

Yang M, Adla S, Temburni MK, Patel VP, Lagow EL, Brady OA, Tian J, Boulos MI, Galileo DS. Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule. Cancer Cell Int. 2009. 29;9:27. (Full Text PDF)


Cooper, CR, Graves, B, Pruitt, F, Chaib, H, Lynch, JE, Cox, AK, Sequeria, L, van Golen, KL, Evans, A, Czymmek, K, Bullard, RS, Donald, CD, Sol-Church, K, Gendernalik, JD, Weksler, B, Farach-Carson, MC, Macoska, JA, Sikes, RA, and Pienta, KJ.  Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-α. J Cellular Biochemistry. 2008. 104: 2298–2309

Brown AJ, Alicknavitch M, D'Souza SS, Daikoku T, Kirn-Safran CB, Marchetti D, Carson DD, Farach-Carson MC. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008. 43(4):689-699. (Full Text PDF)
Griffiths GS, Galileo DS, Reese K, and Martin-DeLeon PA. Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model. Molucular Reproduction and Development. 2008. 75:1627-1636. (Full Text PDF)

Wagner RC and Hossler FE.  Tomographic Modeling of Casted Blood Vascular Systems.  inFocus Magazine. (11) 2008. (Full Text PDF)

Barwe SP, Maul RS, Christiansen JJ, Anilkumar G, Cooper CR, Kohn DB, Rajasekaran AK. Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix. (Int J Oncol. 2007 Apr;30(4):899-904.)  
Deeble PD, Cox ME, Frierson HF, Sikes RA, Palmer JB, Davidson RJ, Casarez EV, Amorino GP, Parsons SJ. Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. (Cancer Res. 2007 Apr 15;67(8):3663-72.)  
Degraff DJ, Malik M, Chen Q, Miyako K, Rejto L, Aguiar AA, Bancroft DR, Cohen P, Sikes RA. Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model. (J Cell Physiol. 2007 May 10;). 
Kendall J, Kendall C, Ali-Khan Catts Z, Radford C, Dasch K. Using adult learning theory concepts to address barriers to cancer genetic risk assessment in the african american community. (J Genet Couns. 2007 Jun;16(3):279-88.) 
Kirn-Safran CB, Oristian DS, Focht RJ, Parker SG, Vivian JL and Carson DD. Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29. Developmental Dynamics. 2007. 236:447-460. 
O'connor JC, Farach-Carson MC, Schneider CJ, Carson DD. Coculture with Prostate Cancer Cells Alters Endoglin Expression and Attenuates Transforming Growth Factor-{beta} Signaling in Reactive Bone Marrow Stromal Cells. (Mol Cancer Res. 2007 Jun;5(6):585-603.) 
O'dwyer PJ, Eckhardt SG, Haller DG, Tepper J, Ahnen D, Hamilton S, Benson AB, Rothenberg M, Petrelli N, Lenz HJ, Diasio R, DuBois R, Sargent D, Sloan J, Johnson CD, Comis RL, O'Connell MJ Priorities in colorectal cancer research: recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. (J Clin Oncol. 2007 Jun 1;25(16):2313-21.) 
Sun, Y-X,  Fang M, Wang J, Cooper CR, Pienta KJ, and Taichman RS. Expression and Activation of avb3 Integrins by SDF-1/CXC12 Increases the Aggressiveness of Prostate Cancer Cells (The Prostate 67: 61-73). (2007). 

Adla S, Temburni MK, Patel VP, Yang M, Lagow E, Cretu A, Tian J, Kudish P, Galileo DS. Stimulation of glioma and breast cancer cell motility by proteolysis and release of the L1 neural cell recognition molecule (AACRP, Apr 2006). 
Chen Q, Watson JT, Marengo SR, Decker KS, Coleman I, Nelson PS, Sikes RA. Gene expression in the LNCaP human prostate cancer progression model: Progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo (Cancer Lett. 2006 Feb 21;).  
Cretu, A, Fotos JS, Little BW, and Galileo DS. Human and rat glioma growth, invasion, and vascularization in a novel chick embryo brain tumor model (Clin Exper Metas, 22, 225-236).  (2005).
Datta MW, Schlicht MJ,DeGueme AM, Kahler AJ, Hernandez AM, Barrett, A Datta S, Dhir R, Shah RB, Farach-Carson C. Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway (Molecular Cancer 2006, 5:9). 
Huang WC, Wu D, Xie Z, Zhau HE, Nomura T, Zayzafoon M, Pohl J, Hsieh CL, Weitzmann MN, Farach-Carson MC, Chung LW. 2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis (Cancer Res. 2006 Sep 15;66(18):9108-16).  
Muir C, Chung LW, Carson DD, Farach-Carson MC. Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells. (Clin Exp Metastasis. 2006;23(1):75-86). 
Ogunnaike, BA. Elucidating the digital control mechanism for DNA damage repair with the p53–Mdm2 system: single cell data analysis and ensemble modelling (J. Roy. Soc. Interface. 3, 175-184, 2006).
Mayawala K, Vlachos DG and Edwards JS. Computational modeling reveals molecular details of epidermal growth factor binding (BioMed Central Cell Biology Research Article, Nov 2005).
McLane MA, Zhang X, Tian J, Zelinskas C, Srivastava A, Hensley B, Paquette-Straub C, Scratching below the Surface: Wound Healing and Alanine Mutagenesis Provide Unique Insights into Interactions between Eristostatin, Platelets and Melanoma Cells (2005). 
Yamaguchi N, Chae B-S, Zhang L, Kiick KL, and Furst EM. Rheological Characterization of Polysaccharide-Poly(ethylene glycol) Star Copolymer Hydrogels (Biomacromolecules 2005, 6, 1931-1940).
Yamaguchi N and Kiick KL. A Polysaccharide-Poly(ethylene glycol) Star Copolymer as a Scaffold for the Production of Bioactive Hydrogels (Biomacromolecules 2005, 6, 1921-1930).

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