The Center for Translational Cancer Research

Kirk J. Czymmek, Ph.D.

Associate Professor, Director CTCR Core Facility

University of Delaware
Department of Biological Sciences
Wolf Hall, Room 309
Newark, DE 19716

 

Phone Number: 
(302) 831-3450

Ph.D., Michigan State University, 1993
B.S., State University of New York - Oswego, 1989 
 


Research Interests: Dr. Czymmek’s lab is interested in using contemporary molecular cytology, preparation, and imaging technologies to understand aspects of fungal cell biology, namely-plant pathogenic interactions and mechanisms of fungal hyphal tip growth. Model systems include the rice pathogen Magnaporthe grisea, which is the causal agent of rice blast disease and is of worldwide economic importance, and Phytophthora phaseoli, which is the causal agent of downy mildew in lima bean a very important processing crop in the Delmarva Peninsula. Currently, Dr. Czymmek’s lab, in collaboration with DuPont Ag Biotech, is utilizing spectral variants of green fluorescent protein (GFP) tagged fungal hyphae and four-dimensional imaging techniques to visualize entire host-pathogen encounter sites in planta, over time. In addition, the lab is involved with in vivo time-course imaging of the effect of fungicides on specific fungal structures and organelles with specific fusion proteins.

 

Manuscripts:

Modla S, Czymmek KJ. 2011. Correlative microscopy: A powerful tool for exploring neurological cells and tissues. Micron. 2011 [Epub ahead of print]
 

Thompson WR, Majid AS, Czymmek KJ, Ruff AL, García J, Duncan RL, Farach-Carson MC. 2011. Association of the α(2) δ(1) subunit with Ca(v) 3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes. J Bone Miner Res. [Epub ahead of print]
 

Huang K, Czymmek KJ, Caplan JL, Sweigard JA, Donofrio NM. 2011. HYR1-mediated detoxification of reactive oxygen species is required for full virulence in the rice blast fungus. PLoS Pathog. Epub Apr 14.
 

Thompson WR, Modla S, Grindel BJ, Czymmek KJ, Kirn-Safran CB, Wang L, Duncan RL, Farach-Carson MC. 2011. Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res. 26:618-629.
 

Danysh BP, Patel TP, Czymmek KJ, Edwards DA, Wang L, Pande J, Duncan MK. 2010. Characterizing molecular diffusion in the lens capsule. Matrix Biol. 29:228-36
 

Shao Y, Czymmek KJ, Jones PA, Fomin VP, Akanbi K, Duncan RL, Farach-Carson MC. 2009. Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells. Am J Physiol Cell Physiol. 296:1067-1078.