Development of a Novel Lymphomimetic System to Study Inflammatory Breast Cancer in vitro
Heather Unger, Erica Dashner, Michelle Lucey, Dr. Kenneth van Golen
Department of Biological Sciences, Laboratory of Cytoskeletal Physiology, University of Delaware
Inflammatory breast cancer (IBC) manifests as tumor emboli in the dermal lymphatics overlying the breast. To date, there has been no way to accurately study these highly invasive emboli. We have developed a method for growing IBC emboli in the laboratory. This is a representative image of an IBC tumor embolus grown in our laboratory that is stained for IBC markers and closely resembles tumor emboli seen in patients. This system will allow us to accurately study IBC in the laboratory.
Acknowledgement: We would like to thank Dr. Rebekah Helton and Dr. Kirk Czymmek, Director of the Bioimaging Center at the Delaware Biotechnology Institute, for their help and expertise in the production of this image. This work is funded by DoD BCRP grant W81XWH-06-1-0495 and W81XWH-08-1-0356.
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