Manager, Molecular Diagnostics and CTCR Christiana Care Health System
4701 Ogletown-Stanton Road
Newark, DE 19713
M.A., MBA., Bryn Mawr College
Szabo, S., L.E. Moffett, K. Cantwell-McNelis, C.W. James, A. Joseph. Low-Level Viremia Associated With the Use of TaqMan Assay. 2010. J. Interatl. Assoc. Phyiic AIDS Care.9:203-205.
Abstract: Poor correlation has been reported between the Roche Cobas AmpliPrep/Cobas (TaqMan) HIV-1 TaqMan assay and the Roche Cobas Amplicor HIV-1 Monitor version 1.5 Amplicor assay. We report 8 patients who experienced unexplained detectable viremia, despite exemplary medication adherence, following a change in viral quantification assay from Amplicor to TaqMan in January 2008. All patients were found to have undetectable HIV RNA by branched DNA (bDNA) assay.